5HT: 5 Healthyish Things, including my 2026 resolutions and GLP-3 entering the chat

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Well, it’s January 1. The day many of us hit play ▶️ on New Year's resolutions and hope for a banger. 

Buuut we all know sticking with resolutions is tough. So over the years, I’ve developed a few healthyish hacks for keeping them. Using those, I landed on four resolutions I’m committing to this year. (So, yes, you’ll be reading a lot about ‘em in 5HT 😂!) 

I share ‘em because one of my hacks is about having an accountabilibuddy (yes, that’s the name I use—I stand by it). I see this newsletter as a source of accountability—where I can share my goals and what actually helps me make progress. It also creates a space to hear yours. (Maybe it’ll even become a future 5HT topic?) So, hit reply and tell me what you’re working toward on 2026 if you need an accountabilibuddy of your own.

In the meantime, here are mine:👇

1️⃣ I get healthier every decade so I can be strong, sharp, joyful, and energetic for myself and my family... and prevent Alzheimer's forever. 

What I’m doing about it: 

2️⃣ I prioritize sleep and rest because it's critical for health and happiness.

What I’m doing about it:

3️⃣ I prioritize quality time with my family and friends because it's healthy, fulfilling, and fun.

What I’m doing about it: 

4️⃣ I take entreprenurial swings for upside outcomes.

What I’m doing about it:

I crushed my 2025 resolutions, so I feel a lot of momentum going into next year and well on my way to becoming more like my #1 man crush, Henry Cavill. 😄

Retatutride is coming 🚨 annnd people are actively trying to get it through nebulous channels. 

Retatutride is not your average GLP-1. It’s a triple agonist, targeting GLP-1, GIP, and GCG, earning it the super cool nickname “triple G” 😎 or “GLP-3” 🤓 if you want to be sciency. (Some just call it “reta.”)

Early trials of retatutride show significantly more fat loss (like… a lot more), less lean mass loss, and deeper metabolic effects than other GLPs. A recent review also showed how these triple agonists outperform current GLP-1s on weight loss, insulin, sensitivity, liver, fat reduction, and cardiovascular risk markers. Eric Topol has been openly bullish on retatutride, calling this class of drugs a meaningful leap forward, not hype. 

The point is: Retatutride looks poised to be a gamechanger. 

Even though it’s not approved in the U.S. yet, a recent piece in The Atlantic details how that's not stopping people from getting it. Demand is clearly outpacing access here and, in fact, an underground retatutride market has emerged via gray-market peptide vendors, sales reps on WhatsApp and Telegram, and crypto payments.

When drugs clearly work and feel transformative—but are difficult to get or cost hundreds of dollars per month—illicit markets don’t reflect a moral failure so much as an economic inevitability, IMO. People want to feel better now. And nothing motivates quite like looking good and feeling good. Pharma can’t (and probably won’t) price these like luxury goods forever. As long as they do, grey markets will exist.

To be very clear: do not go buy GLP-3 from some unnamed supplier. These drugs are still unregulated, dosing is uncertain, and the risk of contamination is real 💉. Please don’t go hunting for GLP-3s in the back alleys of the internet. Buuut getting excited about what’s coming (and what’s already here 👇) is fair game. 

Ozempic cracked the door, yes. Tirzepatide blew it off the hinges. My guess is retatruride will accelerate this shift—and force the medical, economic, and ethical systems around it to catch up fast. I’m excited to watch it happen. 🍿

If you have yet to explore Your Year with ChatGPT, this is your sign to do so. Here’s what ChatGPT says my 2025 looked like and, welp, I think it got me. 😆 Also top 1%, NBD—anyone else get this??

If you’ve been a 5HT reader for a while, you know I went hard on tracking my macros during my weight loss journey. I’ve actually been on a break for a few months, though I'm considering going back to it to support one of my goals this year of getting my body fat down to ~15%.​

I’ve tried so many tracking apps and tools over the years. The one I plan to go back to is Alma—and the reason is simple: Most food tracking fails not because of willpower, but because it’s annoying 😂 and, well, Alma is not! I used to be a die-hard MyFitnessPal user because it had everything. Buuut it also had so many things it felt disorganized 😬, hard to navigate, and often lacking critical information.

With Alma, you can literally say out loud what you ate, and it logs it shockingly well. It understands food context instead of forcing you into dropdown hell. And Alma’s photo logging is the best I’ve seen 🤳—especially for portions and mixed meals. The whole experience feels wayyy more intuitive than other tools I’ve tried.

Now, nobody needs to track calories or macros. IMO the real value for using an app (or even just food journaling) is awareness. It’s in seeing your patterns and understanding where things drift. It’s in learning more about what you’re putting in your body and how many calories guacamole has (worth it). It’s in using all that information to improve and head in a better, more informed direction.

Think of it less as following a rigid plan and more as getting personalized feedback loops to help you eat more intentionally, then step back once you’ve recalibrated. This mindset ultimately aligns with my + Justin Mares’ 2026 predictions on a post-diet culture—aka more intention and less perfection. Alma feels designed for the shift, and I’m excited to get back into it.

Annnd while this isn’t sponsored, I am lucky to call the folks at Alma friends, and they’re giving 5HT readers an exclusive discount. Use “ALMAHEALTHY” to get 50% off their yearly Premium membership.

With 2025 wrapped, I want to say thank you 💚 to everyone who reads 5HT. It started as a place for me to think out loud about health—and, since I wasn’t running a business at the time, a way to stay in the loop on trends and an excuse to read more academic research (not kidding).

Now it’s become something bigger and better, and that’s entirely because of you. Your replies. Your pushback. Your curiosity. I can’t tell you how often someone emails me about a single sentence—not just to agree, but to inform me, challenge me, or add nuance. And I want you to know how awesome I think that is. 

It’s worth saying your health protocol in 2026 likely won’t look like mine—and it shouldn’t! But sharing what we’re testing and thinking helps all of us get closer to what works and what matters.

Personally, I’ve never been more thrilled about the direction we're heading in health, and I look forward to continuing to make sense of it all in a way I hope (🤞) feels accessible, useful, and dare I say, entertaining. As I step (or dance 🕺) into 2026, I’m opting for curiosity over certainty—and I encourage you to do the same.

Here’s to a very healthyish 2026. 🥂

Okay, you now know what I’m curious about—but here’s what everyone else is Googling, according to a few trusty platforms.

👋 Who are you again? I’m Derek Flanzraich—founder of two venture-backed startups in Greatist (👍) and Ness (👎). I’ve worked with brands like GoodRx, Parsley, Midi, Ro, NOCD, and Peloton. I now run Healthyish Content, a premium health content & SEO agency (among other things).

Every Thursday, I share 5 health things I feel strongly about so you can live healthyish. (Disclaimer: I’m more your friend with health benefits. None of this is medical advice.) 

And oh, you also feel strongly about some health things? Hit reply—I’d love to hear it.