
Hey 5HTers 👋! You are officially reading the 100th edition of 5HT 🤯. Very proud centenarian over here 🥲. To celebrate, I’m giving you even more 5HT. I’m calling it… newsletter-maxxing! Starting this Sunday, we’re introducing another weekly edition—one healthyish industry trend to chew on plus more Brain Snacks so you’re always the friend who’s in the know. Let’s keep this serotonin party going, yeah? 🎉
#1 Craniosacral therapy
Next up in my series on the wild world of woo: craniosacral therapy 💆♂️.
Craniosacral therapy, or CST, is a gentle, non-invasive bodywork meant to release tension around the skull, spine, and sacrum.
It’s touted for helping with conditions like headaches, insomnia, constipation, and neck pain. More recently, it’s become popular among babies (er—or for babies?), especially those with latching issues, tongue-ties, colic, or reflux. These days, you can barely open TikTok without seeing a baby melting into bliss during a craniosacral session.
@thiskatestuart This is a slightly longer reel than I’d usually share — but it’s such a lovely example of how a baby can release during Cranio-Sacral Ther... See more
We actually tried CST for our first kiddo, annnnd I don’t think it made any difference 😬. At the time, it felt like one of those things you’re supposed to try as a new parent in Austin. And when your baby is struggling to latch, you’re much more likely to try anything that might help.
CST is based on the idea that subtle manipulation of the skull and sacrum can influence the flow of cerebrospinal fluid and, by extension, the nervous system. Sounds plausible enough. The problem is science doesn’t really support the premise.
Most evidence for CST is anecdotal or unconvincing. One systematic review found CST produces no benefits in any of the MSK or non-MSK conditions assessed, though there is some limited evidence it may help with migraine or headache symptoms in adults.
But, hey, like with all woo, there’s nuance.
Babies can respond intensely to gentle touch, being spoken to softly, slow rhythmic movement, and calm environments. All of that happens during CST. So the effects in those TikTok videos may be real, buuuut it’s more likely nervous system soothing than skull manipulation. (FWIW, adults respond well to that stuff too LOL.)
And look, a reader emailed me last year saying craniosacral therapy seemed to relax their son. I believe it. The anecdotes are real. The mechanism? Still not well-proven. 🤷
My take: CST is probably harmless when done gently and appropriately, and if it helps you or your baby relax, great, but I wouldn’t personally recommend it.
#2 The Lineage Bar
Long-time 5HT readers will know I’ve been big into Lineage Provisions’ beef sticks and healthy snacks. Then, Lineage told me they were launching their first “Protein Bar for Humans,” and I’d be among the earliest people to try them.
To be real, I was pretty nervous.
I’ve tried, er, every healthyish protein bar out there (and even wrote about my experience trying 25+ of them last year). I’m a tough critic. I was really worried I wouldn’t like them and then have to have that very awkward conversation.
Buuut what a relief it is to share that the Lineage Provisions bars are not just good, they’re awesome. I need to try more than a couple (I’ve already ordered more myself), but so far I think they’re actually my new favorite—even better than the ones I ranked previously—and I don’t say that lightly!
Packing 20g of high-quality protein, the macros and ingredients in these bars are as good as it gets, competing with what imo are truly best-in-class bars. They launched with two flavors—Chocolate and Berry—and I got an early taste of both. The Chocolate one was especially delicious. It had the perfect amount of sweetness and a satisfying texture. Think Tootsie Roll (but healthy).
The best part is they’re made with real ingredients that naturally taste good. And not many of them, either! You won’t find 🙅🏻♂️ seed oils, 🙅🏻♂️ sugar alcohols, 🙅🏻♂️ gums, 🙅🏻♂️ emulsifiers, 🙅🏻♂️ fiber syrups, or 🙅🏻♂️ fillers in these bars.
Instead, you’ll find:
💁🏻♂️ Raw honey & coconut nectar for sweetness
💁🏻♂️ Organic cacao or organic berries for flavor
💁🏻♂️ Grass-fed beef tallow for rich, stable fat
If you want a healthyish-approved protein bar you can eat consistently and feel good about, Lineage Provisions gets my full reco. Annnd (!) they're offering 5HT readers 15% off the protein bars to celebrate their re-launch (they sold out in 2.5 days when they first launched, and they’re now back in stock)! 🥳
#3 Toxicity tests
I recently was given the opportunity to take an extreme lab-grade blood test from VibrantAmerica they call Toxin Zoomer, which assesses how everyday toxic exposures and detox pathways shape your health. (Vibrant is among the largest, most respected labs in the world; they mostly work with longevity clinics and concierge doctors.)
The biggest takeaway: I'm not poisoned 👍.
But the fact is, we live on planet Earth, and there's a loooot of toxicity out there.
My report showed traces of phthalates, plastics, pesticides, and heavy metals. Some heavy metal findings (almost certainly) were leftovers from my heart ablation. I also had low-to-moderate markers for air and environmental toxins.
Here’s a look at some:
Zooming out, this reminded me that even healthy people are exposed to lots of low-level stuff, and it’s worth reducing exposure where we can.
Zooming in, there was nothing alarming enough to make me want to build a bunker 😆, but enough to make me think more seriously about supporting detox.
“Detox” is mostly a nonsense word and your body—your liver esp—is pretty good at it already. Buuut it does seem there are some natural ways to help your body do more of it. Think less viral detox teas and foot detox pads 🙄 and more supporting the systems already doing the work.
One lever to look at (and Claude encouraged me to look at) is glutathione production. More on that below.
Ultimately, this is probablyyy a more extreme preventative panel, and I don’t think everyone needs to run out and get one. That said, I found it genuinely interesting because it flagged things that may still be hanging around from my heart ablation.
Would I do it again? Probably, at least to see if what’s leftover goes away—though I can get some of that covered through Function. Relatedly, I actually plan to share more on what early prevention tests I do/don’t do soon.
If you’re curious about toxicity, know that Toxin Zoomer isn’t something you can order yourself online (yet), but you can likely find it at a longevity clinic or ask your doctor about it.
#4 Glutathione
Let’s talk glutathione.
Glutathione is an antioxidant that helps neutralize free radicals and supports natural detoxification pathways. It's composed of three amino acids—glutamate, glycine, and cysteine. I think of it basically like your body’s internal Roomba.

Both Claude and ChatGPT encouraged me to up my glutathione based on my Toxin Zoomer readout. You can take it directly, though standard oral glutathione has mixed bioavailability. Liposomal glutathione is designed to absorb better (I wrote about liposomal supplements here), but it’s also very pricey.
IMO, the smarter play is helping your body make more of its own. So here’s how I’m thinking about supporting it 👇:
Feels obvious to double down on:
Taking glycine (I take 4x 2g Thorne Glycine every night)
Avoiding toxins (continuing my effort to reduce microplastics exposure at home)
Eating sulfur-rich veggies (garlic, onions, and cruciferous vegetables)
Enjoying glutathione-rich fruits (watermelon, avocado, grapefruit)
Opting for lean meats (especially grass-fed)
Feels worth testing:
Taking NAC (or N-acetylcysteine). NAC supplies cysteine (one of those three amino acids) and can support glutathione production. I started taking 1,000mg (500 mg day and night) yesterday! I chose this one from Thorne.
Still feels TBD for me:
Getting NAD+ injections. NAD+ may support your body’s antioxidant systems, but it’s not the obvious first move. (Also still too expensive, IMO.)
Taking sulforaphane. I actually took this for a bit, but found it very $$$ and ultimately wasn’t convinced by the science. Broccoli sprouts are probably the better food-first version. That said, I know many smart people who take it.
Also helpful but less sexy:
Getting good sleep
Exercising regularly
Eating enough protein
#5 Naming your anxiety
Love the concept of naming your anxiety to separate you from the feeling… and there’s actual science behind this too. Turns out labeling emotions can reduce their intensity and help you better regulate them more effectively.
See this week’s Neural Hack to name your anxiety and talk back to it. I named mine Galahad. (Galahad could use a vacation.)
⚡ Neural hacks
Directions: Copy, paste, and fill in the prompt below to personify and then “talk” with your anxiety.
Act as a guided journaling coach with a background in behavioural health. Help me personify my anxiety so I can better understand it, name it, and have productive conversations with it.
Start by asking me a few questions to help me describe what my anxiety feels like, sounds like, and looks like. Then help me give it a name that feels accurate but not judgmental.
Once we name it, guide me through a dialogue where I speak to my anxiety and my anxiety speaks back. Keep the tone supportive, curious, and grounding. Help me uncover what it wants, what it fears, what it needs, and what job it thinks it’s doing.
Don’t make my anxiety the villain. But don’t let it run the meeting either.
End with:
What my anxiety is probably trying to protect
What story it keeps repeating
What I can say back when it gets loud
Start by asking me the first question.
🍿 Brain snacks
David ice cream confirmed. Can’t wait, honestly.
Google’s Fitbit Air formally launches for $99. This is a big deal!
Speaking of, more and more wearables are making a big leap into proactive health. 5HT+ member Shaun C told the chat one of her clients uses AI powered monitors to track movement among older adults. Turns out, one study showed AI reduced falls by ~9%.
Aescape enters insolvency. The rare W for humans these days 😬. My take: they were probably too early, though I also didn’t love the experience.
Jesse & Ben's frozen, seed oil-free french fries announce $10M raise.
PCOS gets a new name: Polyendocrine Metabolic Ovarian Syndrome (PMOS). It’s about time.
Also getting a new name is the period of pre-pregnancy. Meet: "Trimester Zero."
New study shows eating 1 egg/day reduces risk of Alzheimer’s by up to 27% (!). Put an egg on it, okay?
Data shows 50% of Americans under 50 get wellness advice from influencers. And newsletter writers! Amiright??
Oh—and my agency Healthyish Content just published a case study about how we helped Radial achieve 1,556% organic traffic growth 🤯 you should totally check out if you’re into this kind of thing.
Most clicked last week: Ozlo Sleep Buds (which btw are $100 off until 5/18 using this link).
Shoutout to Cory Z, Amy M, Liz P, Jesse L, Donna W, Sharon G, Angela M, John E, Amy M, Sonya M, Amelisa E, Jessica L, and Shaun C for sending emails or contributing to 5HT+ Slack community!
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👋 Who are you again? I’m Derek Flanzraich—founder of two venture-backed startups in Greatist (👍) and Ness (👎). I’ve worked with brands like GoodRx, Parsley, Midi, Ro, NOCD, and Peloton. I now run Healthyish Content, a premium health content & SEO agency (among other things).
Every Thursday, I share 5 health things I feel strongly about so you can live healthyish. (Disclaimer: I’m more your friend with health benefits. None of this is medical advice.) Also some links are affiliate links, but they influence my decisions zero.
Oh, you also feel strongly about some health things? Hit reply—I’d love to hear it.




